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1 Genetic testing for vWD can be done in those breeds for which a genetic test is available, however the genetic test does not necessarily correlate to clinical signs. 1 Thrombopathia (decreased platelet function) is uncommon as a cause of hemorrhage, but can be inherited or secondary to drugs (e.g. aspirin, non-steroidal anti-inflammatory drugs), disease (uremia, liver disease, DIC). A complete medical history, including drug administration o…

…by thrombin) release stores of ultra-high molecular weight vWf from Weibel-Palade bodies, which remain adherent to the endothelial cells or bind to extracellular matrix proteins. Platelet adhesion: Endothelial- and matrix-bound vWf unfurls like a string under shear forces and now this multimeric protein is in the appropriate conformation to capture platelets by rapidly forming (and breaking) bonds with the platelet surface glycoprotein (GP) compl…

…t. Around 15-25% of filtered sodium is absorbed in this segment. 4. Distal tubules: Sodium chloride is absorbed together by a cotransporter, which is inhibited by thiazide diuretics. Around 5% of filtered sodium is absorbed here. 5. Collecting ducts: Here is where fine control over sodium absorption occurs. Sodium is absorbed (in exchange for potassium) passively through open channels in principal cells. These open channels are increased in respo…

…litude of an electrical current. The second type of detector is a side scatter or high angle light scatter detector, which measured light scattered sideways by the platelet. The degree of light scatter is dependent on the complexity or granularity of the platelet and is reported as a frequency distribution curve and as the mean platelet component (MPC) in g/dL. A smaller platelet will scatter less light in a forward direction, resulting in a lowe…

…ee of change in amplitude is a measure of the size (volume) of the RBC with smaller RBC causing less resistance and a lower amplitude. Laser-based hematologic analyzers allow RBC to pass through in single file through a flow cell containing a laser. As the RBC passes through the laser, it is counted as an event (providing a RBC count) but it also scatters the laser light. Two detectors can measure the scattered light. The first is the forward sca…