…ee of change in amplitude is a measure of the size (volume) of the RBC with smaller RBC causing less resistance and a lower amplitude. Laser-based hematologic analyzers allow RBC to pass through in single file through a flow cell containing a laser. As the RBC passes through the laser, it is counted as an event (providing a RBC count) but it also scatters the laser light. Two detectors can measure the scattered light. The first is the forward sca…
…litude of an electrical current. The second type of detector is a side scatter or high angle light scatter detector, which measured light scattered sideways by the platelet. The degree of light scatter is dependent on the complexity or granularity of the platelet and is reported as a frequency distribution curve and as the mean platelet component (MPC) in g/dL. A smaller platelet will scatter less light in a forward direction, resulting in a lowe…
Laser-based platelet analysis Read More »
…ee of change in amplitude is a measure of the size (volume) of the RBC with smaller RBC causing less resistance and a lower amplitude. Laser-based hematologic analyzers allow RBC to pass through in single file through a flow cell containing a laser. As the RBC passes through the laser, it is counted as an event (providing a RBC count) but it also scatters the laser light. Two detectors can measure the scattered light. The first is the forward sca…
Laser-based hemoglobin analysis Read More »
…litude of an electrical current. The second type of detector is a side scatter or high angle light scatter detector, which measured light scattered sideways by the platelet. The degree of light scatter is dependent on the complexity or granularity of the platelet and is reported as a frequency distribution curve and as the mean platelet component (MPC) in g/dL. A smaller platelet will scatter less light in a forward direction, resulting in a lowe…
Laser-based platelet analysis Read More »
…ofile and feline pancreatic lipase immunoassay (fPLI) were initially normal. The cat responded minimally to symptomatic treatment, including antibiotics, maropitant, NSAIDs and IV fluids. Over the course of several days, the cat decompensated further, becoming painful in the abdomen. Abdominal radiographs showed no significant findings and the cat was referred to Cornell University Hospital for Animals (CUHA) for further work up. Upon initial exa…
…g chronic eosinophilic leukemia (CEL), chronic myeloid leukemia (CML), chronic myelomonocytic leukemia (CMMoL), and myelodysplastic syndrome (MDS), to name a few.3,4Â Idiopathic eosinophilia or HES is a diagnosis of exclusion after ruling out the other two categories by extensive testing, such as allergy and parasitism screening, computed tomography for underlying neoplasia, bone marrow aspiration or biopsy, genetic analysis, and immunopheno…
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…nancy, the sample was interpreted as reactive bone with inflammation, rather than a neoplastic process (osteosarcoma) (Question 2). Infectious disease testing (e.g. fungal and bacterial cultures) were recommended to determine an underlying cause for the inflammation (Question 3). Surgical biopsy with histopathologic examination would also be prudent, particularly if cultures are negative. Follow-up Due to the radiologist’s differential of…
…anation On blood smear review, granular blue inclusions were seen in approximately 7% of neutrophils (Figures 1 and 2) and, rarely, eosinophils (Figure 3), consistent with Anaplasma morulae. The infection would explain the fever and thrombocytopenia (Question 1). Confirmation of the bacterial species causing the infection would require polymerase chain reaction (PCR) testing for bacterial DNA (Question 2). The initial normal anion gap metabolic a…
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