…x 2 x 0.5 cm, not painful on palpation, and not freely movable. Fine needle aspirates were taken from the mass for cytologic examination. Examine the representative images of the smears and answer the questions below: What are the cells marked by the red and blue arrows in Figure 2? What are your top differential diagnoses for the structures within the cells in Figures 3 and 4? What additional testing would you recommend? Figure 1:…
…al. The swelling was initially thought to be an interdigital cyst and was treated with an course of antibiotics and a tapering dose of prednisone. The swelling seemed to shrink with treatment but did not resolve completely. At the re-evaluation, the veterinarian performed a fine needle aspirate of the swelling and submitted the smears of the aspirate to the Animal Health Diagnostic Center at Cornell University for examination. Examine the image f…
…detachment in the right and left eyes, respectively. A subretinal aspirate was performed of the left eye and submitted for cytologic evaluation. Evaluate the provided cytologic images (Figures 1-3) and answer the following questions: What differential diagnoses would you have for this patient based on the history? What are the rod-like structures within the macrophages and scattered in the background? What additional tests would you recom…
…ied more frequently now with the use of molecular diagnostics.2,4 The RGM include the M. chelonae-abscessus, M. fortuitum, and M. smegmatis groups, as well as other groups and species.4 The RGM produce three syndromes in cats and dogs: most commonly (1) infectious panniculitis, (2) pyogranulomatous pneumonia, and rarely (3) disseminated systemic disease.4 Examples of the slow growing mycobacteria causing NTMÂ are the closely related M. avium and M…
…t had suffered from abnormal heats (increased frequency, prolonged, split heats). Routine hemogram, biochemical and coagulation testing did not reveal any abnormalities. On abdominal ultrasonographic examination, the uterus was enlarged and dilated and a 5.8 x 4.6 cm mass was noted next to the right cranial uterine horn (Figure 1). The left ovary was normal in appearance. Computerized tomography of the abdomen and thorax revealed a large amount o…
…inflammatory leukogram, consisting of a mild neutrophilia (17.8 thou/µL; reference interval, 2.0-12.0 thou/µL) and mild to moderate monocytosis (3.9 thou/µL, 0.3-2.0 thou/µL). The clinical signs were not alleviated by antibiotics and pain medications, including gabapentin and carprofen. Testing for tick-borne diseases and heartworm was negative and cervical radiographs showed no abnormalities. On physical examination at CUHA, the dog was bright,…
…necessary.7 While calretinin is also reportedly positive in humans mesotheliomas,7,8 this marker has been shown to be inconsistent and unreliable in veterinary medicine.9 Electron microscopy can also be performed to demonstrate microvilli, characteristic of mesothelial cells,9Â however these microvilli are not present in sarcomatous mesotheliomas.7 In humans, mesotheliomas are mainly attributed to exposure to asbestos, which is thought to res…
…on of alveolar macrophages.1,2,5 The onset of clinical signs may be delayed several days, thus a normal initial examination does not rule out exposure. Diagnostic tests should include a complete cell blood count, clotting profile, serum chemistry, urinalysis, arterial blood gas, carbon monoxide concentration, chest radiograph, endoscopy of the upper respiratory tract, and cytologic evaluation of tracheal aspirates.2,4 Due to the likelihood of ede…
…neous and movable mass on the right aspect of the dorsal cervical region was palpated. The rest of her physical examination was unremarkable. Blood samples were obtained and submitted for a complete blood cell count and biochemistry panel and only revealed a mild hyperproteinemia (8.3 g/dL, reference interval, 5.9-7.5 g/dL). Thoracic radiographs and abdominal ultrasound were unremarkable. A computed tomography (CT) revealed a small non-discrete l…
…a Bone aspirate from a dog (low power) Figure 3a. Bone aspirate from a dog (high power).  Additional tests Based on the cytologic results, leg amputation was performed and the diagnosis of osteosarcoma (productive, osteoblastic type) was confirmed on histopathologic examination of the amputated tissue (Figure 4). The marrow space, trabeculae, and cortical bone were infiltrated and replaced by a poorly-demarcated, infiltrative, unencaps…
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