eClinPathFinal4
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Left panel: In acute myeloid leukemia (AML), one or more genetic mutations in a hematopoietic stem cell causes proliferation of the neoplastic clone, outcompeting the residual normal hematopoietic cells (megakaryocytes, erythroid and myeloid progenitors). In many animals, the neoplastic cells spill into blood, resulting in a marked leukocytosis, comprised primarily of tumor cells with single or multiple cytopenias (non-regenerative anemia, neut…
Acute myeloid leukemia Read More »
…ts of tumor self-promotion. Blood. 2014; 124(2), 184-18. ADVIA 2120/ 2120i Hematology Systems Operator’s Guide Computerized User Manual. 2010. Siemens Healthcare Diagnostics Inc Tarrytown, NJ Kelley J, Sharkey LC, Christopherson PW, Rendahl, A. Platelet count and plateletcrit in Cavalier King Charles Spaniels and Greyhounds using the Advia 120 and 2120. Veterinary Clinical Pathology. 2014; 43: 43–49. Schwartz D, Sharkey L, Armstrong PJ, Knudson…
…ic. Pancreatitis would be an alternative diagnosis, but uncommon (as is leptospirosis) in such a young puppy (Question 2). Acute kidney injury (AKI) is one of the most common manifestations of leptospirosis, where the bacterial organisms infiltrate the kidney tissue and cause acute tubulointerstitial nephritis. As the name implies, tubulointerstitial nephritis results from inflammation in the renal tubules and the tissue that surrounds them. The…