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…ncentrated urine (the concentration of which is determined by the degree of tonicity of the medulla). This is accomplished as follows: 1. Normally the glomerular filtrate has a similar osmolality to plasma (300 mOsmol/kg). In the descending limb of the loop of Henle, the NaCl cannot be absorbed, but water is passively resorbed (#1), creating a hypertonic urine (>1200 mOsmol/kg) as it enters the ascending limb. 2. When this NaCl-rich fluid enters…

This dog had a marked leukocytosis (300,000/uL) consisting of large blasts with a concurrent pancytopenia (non-regenerative anemia, neutropenia, severe thrombocytopenia. Some of the cells had coarse red-purple granules. A few eccentrocytes are evident, indicating a degree of oxidant injury (not uncommon in dogs with cancer) (Wright’s stain, 500x magnification). This indicates an acute leukemia, which could be myeloid or lymphoid. A bone m…