Cytology

General interpretation

The microscopic evaluation of the bone marrow is interpreted in conjunction with current hemogram results to try to identify abnormalities.  Some of the more common or important interpretations and descriptions are given below. Descriptive terms Left-shifted maturation: This term is used to indicate that the pyramidal maturation of cells in marrow is not present and that

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Indications/Methods

Indications Indications for bone marrow sampling include: Evaluation of persistent or unexplained abnormalities in peripheral blood, including: Pancytopenia (anemia, usually non-regenerative, neutropenia, thrombocytopenia) Unexplained, persistent, nonregenerative anemia Unexplained, persistent, thrombocytopenia Unexplained, persistent, marked neutrophilia and/or monocytosis Unexplained, persistent, moderate to marked monocytosis Unexplained, persistent, moderate to marked eosinophilia and/or basophilia Unexplained, persistent, marked thrombocytosis Evidence

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Cytologic evaluation

Bone marrow aspirate evaluation should always be performed by a clinical pathologist.  However, you should know what to expect from a bone marrow report and how the findings are interpreted.  Bone marrow evaluation includes an assessment of the following: An estimate of cellularity, evaluation of all hematopoietic lineages (including an M:E ratio), estimation of iron

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