Platelets are captured by long strands of multimeric vWf, which bind to GPIb-IX-V on platelet surfaces with fast on-off rates, forming transient bonds. The binding of vWf to GP1b-IX-V induces inside-out signaling, activating the integrin receptors, GPIIb/IIIa (alphaIIbbeta3) and GPIa/IIa (alpha2beta1
