Dysplasia (cornea)


Corneal scraping from a horse with an ulcer” There is marked neutrophilic inflammation and neutrophils are closely intercalated with the corneal epithelial cells. These are dysplastic because they have higher nuclear to cytoplasmic ratios and deeper blue cytoplasm than normal. They also display mild anisokaryosis and have irregular nuclear and cellular shapes, with several cells being more spindled. These features were attributed to dysplasia secondary to the inflammation versus a tumor, such as a squamous cell carcinoma (they were not keratinizing) (Wright’s stain, 50x objective).