Polyclonal gammopathy


Immunoglobulins produced by lymphocytes and plasma cells in immune responses are of different specificities and immunoglobulin classes and migrate to slightly different points during electrophoresis, forming peaks in the beta and gamma regions that are taller than normal and wider than the albumin peak at both the base and the tip.

Note: The a2 peak may look tall, but the absolute amount of a2 protein (in the chart) is normal, so there is not strong evidence of an acute phase response.

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