Figure 1A: Liver aspirate from a dog


There is a single cluster of hepatocytes with interspersed bile casts (black arrows), indicating cholestasis. Some of the hepatocytes are binucleated (regenerative or reparative response, presumptive) and/or contain lipofuscin granules (black arrowhead) in their cytoplasm. The latter is a “wear and tear” pigment, that is a non-specific finding associated with prior or ongoing liver injury. A hint of copper (red arrow) is seen within the ruptured hepatocyte (Wright’s stain, 50x objective).

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