This dog with pancytopenia (non-regenerative anemia, severe thrombocytopenia, neutropenia) had low numbers of circulating blasts (red arrow) along with dysplastic megakaryocytes (micromegakaryocyte, black arrow) and platelets (arrowhead) (Wright’s stain, 500x magnification). The dog had >20% blasts in bone marrow, many of which were differentiating towards megakaryocytes and showed features of dysplasia. The results confirmed a diagnosis of acute megakaryoblastic leukemia (AML-M7).