Figure 1: Bone marrow aspirate from a dog with acute megakaryoblastic leukemia.

 

Most of the differentiating and immature megakaryocytes, including erythrophagocytic variants, are diffusely and strongly positive in their cytoplasm for alpha-naphthyl butyrate esterase (ANBE), a marker of monocytes and megakaryocytes in dogs. Note the nuclear atypia in the cells (50x objective).

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