Figure 4 Bone marrow aspirate from a dog with acute megakaryoblastic leukemia.

 

This figure illustrates the “ruffling” or cytoplasmic blebbing seen around the periphery of some cells. In this case, the cell is multinucleated or multilobulated and resembles a megakaryocyte, albeit dysplastic. Ruffling is a characteristic finding, when present, of blasts that are of megakaryocytic origin. note how some of the other adjacent blasts have a few clear cytoplasmic vacuoles, another finding in neoplastic megakaryocytes (Wright’s stain, 100x objective, cropped).

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