Production Neutrophils are produced in the bone marrow from the hematopoietic stem cell under the influence of neutrophilopoietic cytokines, such as granulocyte- (G-CSF) and granulocyte-monocyte stimulating factor (GM-CSF). These cytokines are produced by marrow stromal cells, including T lymphocytes (GM-CSF). Neutrophils are produced daily and normally have a circulating lifespan of <24 hours in humans … Continue reading Neutrophils